While precise data is unavailable, estimates suggest a lifetime prevalence of benzodiazepine use disorder to be less than 1%. Diazepam became widely popular, and between 19, it was the most prescribed drug in the United States, with over 2.3 billion doses sold in its peak year in 1978. He later developed an improved, safer version named diazepam in 1963. In 1956, he serendipitously created chlordiazepoxide, which was approved for medical use in 1960. Leo Sternbach was an Austrian scientist working for Hoffmann-La Roche in Nutley, NJ, and has been accredited for his work in developing many drugs, in particular, benzodiazepines. Today, there are over 50 different agents available on the worldwide market, and the high incidence of benzodiazepine overdose mirrors their widespread use and availability.
Due to their many uses and addictive properties, benzodiazepines have been widely prescribed and abused since their development several decades ago. Benzodiazepines are currently used to treat anxiety, seizures, withdrawal states, insomnia, agitation and are commonly used for procedural sedation. Since their initial development, multiple benzodiazepine drugs have been developed over the course of several decades. Since the 1960s, with the development of chlordiazepoxide and shortly thereafter diazepam, benzodiazepines quickly became popular medications secondary to their vastly superior safety profiles when compared to previous sedative-hypnotics such as barbiturates and other non-barbiturates used for the treatment of anxiety and insomnia. Summarize interprofessional team strategies for improving care coordination and communication to advance the treatment of benzodiazepine toxicity and improve outcomes.Outline the treatment and management options available for benzodiazepine toxicity.Review the presentation of a patient with benzodiazepine toxicity.Identify the epidemiology of benzodiazepine toxicity.This activity reviews the pathophysiology, presentation, and etiology of benzodiazepine toxicity and highlights the role of the interprofessional team in the management of these patients. Benzodiazepines are currently used to treat anxiety, seizures, withdrawal states, insomnia, agitation, and are commonly used for procedural sedation. Since the 1960s, with the development of chlordiazepoxide and shortly thereafter diazepam, benzodiazepines quickly became popular medications secondary to their vastly superior safety profiles when compared to previous sedative-hypnotics such as barbiturates and other non-barbiturates used for the treatment of anxiety and insomnia.
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